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LnRiLWNvbnRhaW5lciAudGItY29udGFpbmVyLWlubmVye3dpZHRoOjEwMCU7bWFyZ2luOjAgYXV0b30gLndwLWJsb2NrLXRvb2xzZXQtYmxvY2tzLWNvbnRhaW5lci50Yi1jb250YWluZXJbZGF0YS10b29sc2V0LWJsb2Nrcy1jb250YWluZXI9IjkyYmRmZGIxOGE0ZGJiNTQ5NzYxMGMwODZhMTE3MTc0Il0geyBib3JkZXItcmFkaXVzOiAxNXB4O3BhZGRpbmc6IDI1cHg7bWFyZ2luLXRvcDogMTBweDtib3JkZXI6IDFweCBzb2xpZCByZ2JhKCAwLCAwLCAwLCAxICk7ZGlzcGxheTptcy1mbGV4Ym94ICFpbXBvcnRhbnQ7ZGlzcGxheTpmbGV4ICFpbXBvcnRhbnQ7LW1zLWZsZXgtZGlyZWN0aW9uOmNvbHVtbjtmbGV4LWRpcmVjdGlvbjpjb2x1bW47LW1zLWZsZXgtcGFjazpjZW50ZXI7anVzdGlmeS1jb250ZW50OmNlbnRlcjsgfSAud3AtYmxvY2stdG9vbHNldC1ibG9ja3MtY29udGFpbmVyLnRiLWNvbnRhaW5lcltkYXRhLXRvb2xzZXQtYmxvY2tzLWNvbnRhaW5lcj0iOTJiZGZkYjE4YTRkYmI1NDk3NjEwYzA4NmExMTcxNzQiXSA+IC50Yi1jb250YWluZXItaW5uZXIgeyBtYXgtd2lkdGg6IDEwMCU7IH0gLndwLWJsb2NrLXRvb2xzZXQtYmxvY2tzLWNvbnRhaW5lci50Yi1jb250YWluZXJbZGF0YS10b29sc2V0LWJsb2Nrcy1jb250YWluZXI9IjkyYmRmZGIxOGE0ZGJiNTQ5NzYxMGMwODZhMTE3MTc0Il0gcCB7IGZvbnQtZmFtaWx5OiBVYnVudHU7Zm9udC13ZWlnaHQ6IHJlZ3VsYXI7Y29sb3I6IHJnYmEoIDAsIDAsIDAsIDEgKTsgfSBAbWVkaWEgb25seSBzY3JlZW4gYW5kIChtYXgtd2lkdGg6IDc4MXB4KSB7IC50Yi1jb250YWluZXIgLnRiLWNvbnRhaW5lci1pbm5lcnt3aWR0aDoxMDAlO21hcmdpbjowIGF1dG99IH0gQG1lZGlhIG9ubHkgc2NyZWVuIGFuZCAobWF4LXdpZHRoOiA1OTlweCkgeyAudGItY29udGFpbmVyIC50Yi1jb250YWluZXItaW5uZXJ7d2lkdGg6MTAwJTttYXJnaW46MCBhdXRvfSB9IA==
Previous studies suggest that Autism Spectrum Disorder (ASD) is associated with cardiometabolic diseases, but the full risk profile in autistic individuals remains
unclear. Most existing evidence comes from small sample sizes. To address this, we conducted a large-scale cohort study using data from the entire population of the
Netherlands, comprising, after exclusion criteria, over 8 million individuals. We investigated prospective associations between ASD and various cardiometabolic diseases, including hypertension, diabetes, dyslipidemia, stroke, angina pectoris, myocardial infarction, and heart failure. We applied Cox proportional-hazards models
to examine these associations, adjusting for multiple confounders. Additionally, we performed subgroup analyses to explore variations in risk by sex and age group. Due to the complexity of these analyses, the powerful computational resources of OSSC was required. Our results showed that individuals with ASD had an increased risk of developing cardiometabolic conditions, particularly hypertension, dyslipidemia, diabetes, and stroke.
Photo by Olena Bohovyk on Unsplash
